Aryl Hydrocarbon Receptor (AhR) Regulates Silica-Induced Inflammation But Not Fibrosis
نویسندگان
چکیده
منابع مشابه
Wistar Han Aryl Hydrocarbon Receptor (AhR)
Unknown, but the effects seem limited. Rats homozygous for the mutant allele have a dramatically increased LD50 for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and PCDD (penta-), but not HCDD (hexa-). Overall, the tissue distribution and excretion of TCDD in rats homozygous for the AhR mutation is similar to that of the Long-Evans rat, which was used as a dioxin-sensitive control strain. Reprodu...
متن کاملInteractions between aryl hydrocarbon receptor (AhR) and hypoxia signaling pathways.
Most if not all of the toxic responses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are mediated through the AhR, which requires ARNT to regulate gene expression. ARNT is also required by HIF-1alpha to enhance the expression of various genes in response to hypoxia. Since both the AhR and hypoxia transcriptional pathways require ARNT, some of the effects of TCDD and similar types of ligands cou...
متن کاملThe aryl hydrocarbon receptor: studies using the AHR-null mice.
The aryl hydrocarbon receptor (AHR) is believed to mediate the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), polychlorinated biphenyls, and polycyclic aromatic hydrocarbons. AHR is a member of the Per, ARNT, Sim/basic-helix-loop-helix superfamily of ligand-activated transcription factors that also harbors the transcription factors involved in the hypoxia response, development of ...
متن کاملAmelioration of TCDD-induced teratogenesis in aryl hydrocarbon receptor (AhR)-null mice.
The aryl hydrocarbon receptor (AhR) mediates many of the biological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and transcriptional activation of genes encoding a number of xenobiotic metabolizing enzymes. Prenatal exposure of mice to TCDD causes severe alterations in embryo and fetal development, including hydronephrosis and cleft palate. However, the mechanisms underlying these effe...
متن کاملAryl Hydrocarbon Receptor (AhR) Modulates Cockroach Allergen-Induced Immune Responses through Active TGFβ1 Release
BACKGROUND Aryl hydrocarbon receptor (AhR), a multifunctional regulator that senses and responds to environmental stimuli, plays a role in normal cell development and immune regulation. Recent evidence supports a significant link between environmental exposure and AhR in the development of allergic diseases. We sought to investigate whether AhR plays a role in mediating cockroach allergen-induc...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2012
ISSN: 1096-0929,1096-6080
DOI: 10.1093/toxsci/kfs024